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Home » ... » - Faculty » Faculty Pages » Czuprynski, Charles J. |
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Czuprynski, Charles J.
 Charles J. Czuprynski, PhD
Professor
Research Area: Stromal Cells. Cytokines. PAHs. Leukotoxin. Endotoxin. Endothelial Cells. Modulation of immune response by environmental toxicants, role of apoptosis in the biological response to bacterial toxins.
Home Dept: School of Veterinary Medicine
Affiliated Depts: Molecular and Environmental Toxicology; Pathobiological Sciences
Address
Veterinary Medicine
4174 Veterinary Medicine
2015 Linden Drive
Madison, WI 53706
608/262-8102 - Email
Milestones
2006 - Named director of food safety labatory
Research
The primary interest of our laboratory is studying mechanisms of perturbation of the immune system by microbes and environmental and microbial toxins. Under this broad heading, there are four major active projects: - Immunotoxicology – adverse effects of polycyclic aromatic hydrocarbons on bone marrow cells and hematopoiesis;
- Bovine respiratory disease - focus on viral/bacterial synergism and the effects of Mannheimia haemolytica and its leukotoxin on the activities of bovine leukocytes;
- Haemophilus somnus – adverse effects on bovine endothelial cells as it relates to vasculitis;
- Host and bacterial factors that influence the pathogenesis of gastrointestinal listeriosis.
Publications- Behling-Kelly E, Czuprynski CJ. Endothelial cells as active participants in veterinary infections and inflammatory disorders. Anim Health Res Rev. 2007 8(1):47-58.
- Atapattu DN, Czuprynski CJ. Mannheimia haemolytica leukotoxin binds to lipid rafts in bovine lymphoblastoid cells and is internalized in a dynamin-2- and clathrin-dependent manner. Infect Immun. 2007 75(10):4719-27.
- Kuckleburg CJ, McClenahan DJ, Czuprynski CJ. PLATELET ACTIVATION BY HISTOPHILUS SOMNI AND ITS LIPOOLIGOSACHARRIDE INDUCES
ENDOTHELIAL CELL PROINFLAMMATORY RESPONSES AND PLATELET INTERNALIZATION. Shock. 2007 Jul 19; [Epub ahead of print]. - Woo SR, Barletta RG, Czuprynski CJ. Extracellular ATP Is Cytotoxic to Mononuclear Phagocytes but Does Not Induce Killing of Intracellular Mycobacterium avium subsp. paratuberculosis. Clin Vaccine Immunol. 2007 14(9):1078-83.
- Kuckleburg CJ, Elswaifi SF, Inzana TJ, Czuprynski CJ. - Expression of phosphorylcholine by Histophilus somni induces bovine platelet aggregation. Infect Immun. 2007 75(2):1045-9.
- Behling-Kelly E, Vonderheid H, Kim KS, Corbeil LB, Czuprynski CJ. Roles of cellular activation and sulfated glycans in Haemophilus somnus adherence to bovine brain microvascular endothelial cells. Infect Immun. 2006 Sep;74(9):5311-8.
- Galvan N, Page TJ, Czuprynski CJ, Jefcoate CR. 2006. Benzo(a)pyrene and 7,12-dimethylbenz(a)anthrecene differentially affect bone marrow cells of the lymphoid and myeloid lineages. Toxicol Appl Pharmacol. 213:105-116.
- Atapattu DN, Czuprynski CJ. 2005. Mannheimia haemolytica leukotoxin induces apoptosis of bovine lymphoblastoid cells (BL-3) via a caspase-9-dependent mitochondrial pathway. Infect Immun. 73(9):5504-13.
Check PubMed for other publications by Charles J. Czuprynski
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