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Home » ... » - Faculty » Faculty Pages » Oberley, Terry D |
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Oberley, Terry D
Terry D. Oberley
Professor
Research Area: Oxidation. Cancer. Cell Cycle. Redox. Advanced Microscopy. Cellular and Genetic Toxicology. Role of reactive oxygen metabolism in cell division and carcinogenesis.
Home Dept: Pathology & Laboratory Medicine, School of Medicine and Public Health
Affiliated Depts: Molecular and Environmental Toxicology
Address
7153 WIMR
1111 Highland Ave
Madison, WI 53705
Phone: 608/265-6068 - Email
Research
Research in my laboratory centers on understanding the role of reactive oxygen species in neoplasia. Because reactive oxygen species are substrates for antioxidant enzymes, I am also studying the role of antioxidant enzymes in cancer. It has been suggested in many experimental tumor models that a prooxidant state may be involved in carcinogenesis. It has also been established that lowered antioxidant enzymes are a general property of neoplastic cells. My laboratory is currently studying the effect of transfection of cDNAs for antioxidant enzymes into tumor cells. Studies in malignant melanoma, fibrosarcoma, and breast cancer have all demonstrated that transfection completely inhibits the malignant phenotype as shown in nude mice cell transplantation assays. The mechanism of inhibition of tumor formation remains unknown. Since it is now well established that cellular reduction-oxidation (redox) state affects signal transduction pathways which regulate cell division, I am currently measuring redox in cells transfected with antioxidant enzymes to see if there is direct correlation with inhibition of the malignant phenotype. If a direct correlation between redox and inhibition of malignancy can be demonstrated, new cancer treatment therapies can rapidly be proposed and tested.
Publications- Zhao Y, Chaiswing L, Bakthavatchalu V, Oberley TD, St Clair DK. Ras mutation promotes p53 activation and apoptosis of skin keratinocytes. Carcinogenesis. 2006 Aug;27(8):1692-8. Epub 2006 Apr 12.
- Zhao Y, Wang LM, Chaiswing L, Yen HC, Oberley TD, Lien YC, Lin SM, Mattson MP, St Clair D. Tamoxifen protects against acute tumor necrosis factor alpha-induced cardiac injury via improving mitochondrial functions. Free Radic Biol Med. 2006 Apr 1;40(7):1234-41. Epub 2005 Dec 9.
- Lien YC, Lin SM, Nithipongvanitch R, Oberley TD, Noel T, Zhao Q, Daosukho C, St Clair DK. Tumor necrosis factor receptor deficiency exacerbated Adriamycin-induced cardiomyocytes apoptosis: an insight into the Fas connection. Mol Cancer Ther. 2006 Feb;5(2):261-9.
- Li Y, Wheeler DL, Alters W, Chaiswing L, Verma AK, Oberley TD. Early epidermal destruction with subsequent epidermal hyperplasia is a unique feature of the papilloma-independent squamous cell carcinoma phenotype in PKCepsilon overexpressing transgenic mice.
Toxicol Pathol. 2005;33(6):684-94. - Kim A, Oberley LW, Oberley TD. Induction of apoptosis by adenovirus-mediated manganese superoxide dismutase overexpression in SV-40-transformed human fibroblasts. Free Radic Biol Med. 2005 Nov 1;39(9):1128-41.
- Cole MP, Chaiswing L, Oberley TD, Edelmann SE, Piascik MT, Lin SM, Kiningham KK, St Clair DK. The protective roles of nitric oxide and superoxide dismutase in adriamycin-induced cardiotoxicity. Cardiovasc Res. 2006 Jan;69(1):186-97. Epub 2005 Sep 12.
- Chaiswing L, Cole MP, Ittarat W, Szweda LI, St Clair DK, Oberley TD. Manganese superoxide dismutase and inducible nitric oxide synthase modify early oxidative events in acute adriamycin-induced mitochondrial toxicity. Mol Cancer Ther. 2005 Jul;4(7):1056-64.
- Zhao Y, Chaiswing L, Velez JM, Batinic-Haberle I, Colburn NH, Oberley TD, St Clair DK. p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase. Cancer Res. 2005 May 1;65(9):3745-50./li>
- Zhao Y, Chaiswing L, Oberley TD, Batinic-Haberle I, St Clair W, Epstein CJ, St Clair D. A mechanism-based antioxidant approach for the reduction of skin carcinogenesis. Cancer Res. 2005 Feb 15;65(4):1401-5.
- Kim A, Murphy MP, Oberley TD. Mitochondrial redox state regulates transcription of the nuclear-encoded mitochondrial protein manganese superoxide dismutase: a proposed adaptive response to mitochondrial redox imbalance. Free Radic Biol Med. 2005 Mar 1;38(5):644-54.
Check PubMed for other publications by Terry D. Oberley
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