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Spiegelman, Vladimir S.
 Vladimir S. Spiegelman, MD, PhD
Associate Professor
Research Area: Cancer. Signal Transduction. Mechanisms that govern the turnover of short-lived mRNAs that encode important tumorigenesis regulators (for example, mRNA of b- transducin repeat-containing proteins, b-TrCP1) and the implications of this turnover in signal transduction, embryogenesis, and in tumor development, with major emphasis on skin, colorectal, breast, and prostate carcinogenesis.
Home Dept: Dermatology, School of Medicine and Public Health
Affiliated Depts: Molecular and Environmental Toxicology
Address
436 Medical Sciences
1300 University Ave
Madison, WI 53706
Phone: 608/265-8197 - Email
Research
Molecular Mechanisms of Cancer Development and Progression
Publications- Poenitzsch, A.M., Setaluri, V., Spiegelman, V.S. (2011). (Mela)statin’ the not so obvious: tumor suppressor hidden in intron. Pigment Cell Melanoma Research. 24, 263-5
- Role of â-TrCP ubiquitin ligase receptor in UVB mediated responses in skin. Bhatia N, Demmer TA, Sharma AK, Elcheva I, Spiegelman VS. Arch Biochem Biophys. 2011 Apr 15;508(2):178-84. Epub 2010 Dec 25
- Transcriptional Regulation of CRD-BP by c-myc: Implications for c-myc Functions. Noubissi FK, Nikiforov MA, Colburn N, Spiegelman VS. Genes Cancer. 2010 Oct;1(10):1074-82
- MicroRNA-340-mediated degradation of microphthalmia-associated transcription factor mRNA is inhibited by the coding region determinant-binding protein. Goswami S, Tarapore RS, Teslaa JJ, Grinblat Y, Setaluri V, Spiegelman VS. J Biol Chem. 2010 Jul 2;285(27):20532-40. Epub 2010 May 3
- Noubissi FK, Goswami S, Sanek NA, Kawakami K, Minamoto T, Moser A, Grinblat Y, Spiegelman VS. Wnt signaling stimulates transcriptional outcome of the Hedgehog pathway by stabilizing GLI1 mRNA. Cancer Res. 2009 Nov 15;69(22):8572-8. Epub 2009 Nov 3.PMID: 19887615
- Elcheva I, Goswami S, Noubissi FK, Spiegelman VS. CRD-BP protects the coding region of betaTrCP1 mRNA from miR-183-mediated degradation. Mol Cell. 2009 Jul 31;35(2):240-6.PMID: 19647520
- Elcheva I, Tarapore RS, Bhatia N, Spiegelman VS. Overexpression of mRNA-binding protein CRD-BP in malignant melanomas. Oncogene. 2008 Aug 28;27(37):5069-74. Epub 2008 May 5.PMID: 18454174
- Thiyagarajan S, Bhatia N, Reagan-Shaw S, Cozma D, Thomas-Tikhonenko A, Ahmad N, Spiegelman VS. Role of GLI2 transcription factor in growth and tumorigenicity of prostate cells. Cancer Res. 2007 Nov 15;67(22):10642-6.PMID: 18006803
- Spiegelman V.S.,. Slaga T.J., Pagano M., Minamoto T., Ronai Z., Fuchs S.Y. Wnt/b-catenin signaling induces the expression and activity of bTrCP ubiquitin ligase receptor. 2000, Molecular Cell, 5, 877-882.
- Spiegelman V.S., Stavropoulos P., Latres E., Pagano M., Ronai Z., Slaga T.J, Fuchs S.Y. Induction of b-TrCP by JNK signaling and its role in the activation of NF-kB. 2001, JBC, 276: 29, 27152-27158
- Spiegelman V.S., Tang W., Chan A. M., Igarashi M., Aaronson S. A., Sassoon D. A., Katoh M., Slaga T. J. and Fuchs S. Y. Induction of Homologue of Slimb Ubiquitin Ligase Receptor by Mitogen Signaling. 2002, JBC, 277: 39, 36624-36630
- Bhatia N., Herter J. R., Slaga T. J., Fuchs S. Y., and Spiegelman V. S.* Mouse homologue of HOS (mHOS) is overexpressed in skin tumors and implicated in constitutive activation of NF-kB, Oncogene, 2002, 21, 1501-1509
- Bhatia N., and Spiegelman V. S. Activation of Wnt/b-catenin/Tcf signaling in mouse skin carcinogenesis. 2005, Molecular Carcinogenesis, 42, 213-221.
- Noubissi F., Elcheva I., Bhatia N., Shakoori A., Ougolkov A., Liu J., Minamoto T., Ross J., Fuchs S.Y., and Spiegelman V.S. CRD-BP mediates stabilization of bTrCP1 and c-myc mRNA in response to b-catenin signaling. 2006, Nature, 441, 898-901.
- Bhatia N., Elcheva I., Saleem M., Dlugosz A., Mukhtar H., and Spiegelman V. S. Gli2 is targeted for ubiquitination and degradation by b-TrCP ubiquitin ligase receptor. 2006, JBC, 281: 28, 19320-19326
Check PubMed for other publications by Vladimir S. Spiegelman
Vladimir Speigelman (left)
Rohinton Tarapore (right)
Photo Credit: Chris Frazee, Media Solutions (bottom photo only)
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