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Home » ... » - Faculty » Faculty Pages » Dove, William |
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Dove, William
 William Dove, PhD
Professor
Research Area:
Home Dept: Oncology; School of Medicine and Public Health
Affiliated Depts: Molecular and Environmental Toxicology
Address
313a McArdle Cancer Research
1400 University Ave
Madison, WI 53706
(608) 262-4977 - Email
Research
A developmental mutation detected by its strong effect on neoplasia is the Multiple intestinal neoplasia (Min) allele of the murine Apc gene (adenomatous polyposis coli). A network of genes impinging on its neoplastic phenotypes is being discovered.
One modifier locus, Mom1, confers tumor resistance by encoding a locally active secretory phospholipase. A second modifier locus, Dnmt, seems to control by DNA methylation the activity of a negative regulator of tumor growth. The range of action of modifying genes and their effects on the clonal structure of intestinal tumors are being studied in chimeric mice.
Representative Publications- "Supplementation by vitamin D compounds does not affect colonic tumor development in vitamin D sufficient murine models". Irving AA, Halberg RB, Albrecht DM, Plum LA, Krentz KJ, Clipson L, Drinkwater N, Amos-Landgraf JM, Dove WF, Deluca HF. Arch Biochem Biophys. 2011 Sep 1. [Epub ahead of print]. PMID: 21907701
- Kwong LN, Dove WF. - APC and its modifiers in colon cancer. Adv Exp Med Biol. 2009;656:85-106.
- Durkee BY, Shinki K, Newton MA, Iverson CE, Weichert JP, Dove WF, Halberg RB. - Longitudinal assessment of colonic tumor fate in mice by computed tomography and optical colonoscopy. Acad Radiol. 2009 Dec;16(12):1475-82.
- Huttlin EL, Chen X, Barrett-Wilt GA, Hegeman AD, Halberg RB, Harms AC, Newton MA, Dove WF, Sussman MR. - Discovery and validation of colonic tumor-associated proteins via metabolic labeling and stable isotopic dilution. Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17235-40.
- Halberg RB, Waggoner J, Rasmussen K, White A, Clipson L, Prunuske AJ, Bacher JW, Sullivan R, Washington MK, Pitot HC, Petrini JH, Albertson DG, Dove WF. - Long-lived Min mice develop advanced intestinal cancers through a genetically conservative pathway. Cancer Res. 2009 Jul 15;69(14):5768-75.
- Halberg RB, Chen X, Amos-Landgraf JM, White A, Rasmussen K, Clipson L, Pasch C, Sullivan R, Pitot HC, Dove WF. - The pleiotropic phenotype of Apc mutations in the mouse: allele specificity and effects of the genetic background. Genetics. 2008 Sep;180(1):601-9. Epub 2008 Aug 24.
- Bilger A, Sullivan R, Prunuske AJ, Clipson L, Drinkwater NR, Dove WF. - Widespread hyperplasia induced by transgenic TGFalpha in ApcMin mice is associated with only regional effects on tumorigenesis. Carcinogenesis. 2008 Sep;29(9):1825-30.
- Kwong LN, Shedlovsky A, Biehl BS, Clipson L, Pasch CA, Dove WF. - Identification of Mom7, a novel modifier of Apc(Min/+) on mouse chromosome 18. Genetics. 2007 Jun;176(2):1237-44.
- Amos-Landgraf JM, Kwong LN, Kendziorski CM, Reichelderfer M, Torrealba J, Weichert J, Haag JD, Chen KS, Waller JL, Gould MN, Dove WF. - A target-selected Apc-mutant rat kindred enhances the modeling of familial human colon cancer. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4036-41.
Check PubMed for other publications by William F. Dove
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