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Faculty
AHMAD, Nihal, PhD - Associate Professor, Dermatology. Affiliated with METC since 2003. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant - Prostate, Breast and Skin Carcinogenesis. Tumor Promotion/Prevention. Molecular mechanism of UV-mediated carcinogenesis; signal transduction (especially regulation of cell cycle and apoptosis) in tumor promotion and prevention. Advisor to METC Graduate Students: Brittney Jung-Hynes (current), Travis Schmit (current)
ALBRECHT, Ralph, PhD - Professor, Animal Sciences. Affiliated with METC since 1976. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Organophosphate Immunoactivity. Biocompatibility. Imaging. Microscopy. Effects of toxicants on structure and function of immunoactive cells and on regulatory mechanisms influencing immune responses. Biocompatibility; biological responses to artificial materials used to repair or replace tissues and organs. Mentor to METC Post-Docs: Linda Lutz (1989-1990)
ALLEN-HOFFMANN, B. Lynn, PhD - Professor, Pathology & Laboratory Medicine. Affiliated with METC since 1989. TRAINER and Deputy PI on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Epithelial Differentiation and Carcinogenesis. Discovered and characterized mechanism of Ah receptor activations affected by disruption of cell adhesion. Role of Ah receptor and other bHLH-PAS family members in development and xenobiotic induced pathogenesis of human stratified squamous epithelia. Tissue engineered human models for toxicity testing. Advisor to METC Graduate Students: Elyse Bolterstein (current), Nadira DeAbrew (2007), Lisa VanPay (2006), Jennifer Loertscher (2001), Kris Sachsenmeler (2001), Christine Sadek (1995), Mentor to METC Post-Docs: Lori White (1996-1997)
ANDREN, Anders W, PhD - Professor, Civil and Environmental Engineering. Affiliated with: Environmental Chemistry & Technology Program; METC; Institute of Environmental Studies; Sea Grant Institute; Water Resources Institute. Limnology & Marine Science Program. Research Interests: Sources, transport and fate of toxic substances and nutrients in aquatic systems. Role of the atmosphere in regulating chemical composition of lakes. Advanced water and sediment remediation technologies. Fluid- Phase Equilibria. Ecotoxicology. Global observation systems.
BALSER, Teresa (Teri), PhD - Associate Professor, Soil Science. Affiliated with METC since 2002. Ecophysiology. Microbial Community. Global Change. Nutrient Cycling. Carbon Storage. Lipid Analysis. Role of bacterial ecophysiology in soil process. Specifically, microorganismal response to environmental stress; how response alters behavior, survival, and activity; effect on nitrate production and consumption, degradation of resistant chemicals, and interactions within the plant rhizosphere. Microbial community ecology.
BJORLING, Dale, DVM - Professor, Surgical Sciences. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. Inflammation of the bladder due to non-infectious causes; control of smooth muscle tone by neuropeptides. Roles of environmental estrogenic compounds in bladder disorders, including malignant transformation of bladder epithelial cells. General Surgery: primarily the urinary tract, thorax, biliary tract.
BLEAM, William (Will) F, PhD - Professor, Soil Science. Affiliated with METC since 1999. Toxicant Behavior and Remediation. Imaging. Environmental Chemistry. Fate and transport of compounds in soil environments, using such methods as magnetic resonance and x-ray absorption spectroscopies. Mentor to METC Graduate Student: Lynn Diener (2005)
BRADFIELD, Christopher A., PhD - Director, METC, Professor of Oncology. Affiliated with METC since 1996. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Signal Transduction of PAS proteins. Mechanisms of environmental sensing, e.g., pollution, hypoxia and light. Application of mouse and yeast genetics to understand toxicant signal transduction pathways. Toxicology of dioxins, PCBs and PAHs by Ah receptor and ARNT. Regulation of xenobiotic metabolism. Developmental toxicology. Advisor to METC Graduate Students: Brian Johnson (present), Maureen Bunger (2001) Mentor to METC Post-Docs: Erin Hsu (2007-2008), Suzanne Williams (2004-2006), John La Pres (1997-1998)
BRESNICK, Emery, PhD - Professor, Pharmacology. Affiliated with METC in June 2009.
BUSHMAN, Wade, MD, PhD - Professor, Surgery. Affiliated with METC since 2002. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Human Development / Teratogenicity. Prostate. Sonic Hedgehog. BMP-4. Inhibition of tumor growth by cyclopamine, and Shh signaling as a therapeutic target in prostate cancer. Advisor to METC Graduate Students: Letitia Wong (current), Min Yu (current), Bayli Boehm (MS-2009), Rob Lipinski (2008) - Mentor to METC Post-Docs: Travis Jerde (2009-2010; 2006-2007)
CEZAR, Gabriela, PhD - Assistant Professor, Animal Sciences. Affiliated with METC since 2006. Endocrinology-Reproductive Physiology. Stem cells for toxicology testing. Advisor to METC Graduate Students: Ashley Poenitzsch (current)
COOK, Mark E, PhD - Professor, Animal Sciences. Affiliated with METC since 1987. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Conjugated Linoleic Acid. Immunity. Inflammation. Cytokines. Cachexia. Lipids. Mode of action in chemicals, heavy metals, and nutrients in metabolism, immunity and disease. Advisor to METC Graduate Students: Guangming Li (2004), Danielle Devoney (1999), Natalie DiNicola (1995)
CZUPRYNSKI, Charles J, PhD - Professor, Pathobiological Sciences. Affiliated with METC since 1990. TRAINER and PI on the METC NIEHS Short-Term Research Training for Minority Students Grant. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. Investigating interactions amongst stromal cells, cytokines, and progenitor cells in disruption of hematopoiesis by PAHs. Also studies the effects of bacterial leukotoxins and endotoxin on leukocytes and endothelial cells. Investigating the importance of the AhR in innate immunity to bacterial infection. Advisor to METC Graduate Students: Shawn Heidel (1999) and Paul Stevens (Masters-1995) Mentor to METC Post Docs: Todd Page (2003), Alice Yuroff (2004) and Alhaji N'jai (2007)
DOVE, William, PhD - Professor, Oncology - Affiliated with METC in 2008. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant, Advisor to METC Graduate Student: Amy Irving (current),
DRINKWATER, Norman R, PhD - Professor. Affiliated with METC since 1987. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant, Genetics of Chemical Carcinogenesis and Mutagenesis. Molecular mechanisms of carcinogenesis and mutagenesis. Genetic susceptibility to carcinogenesis. Advisor to METC Graduate Students: Mara Feld (2008)
EISENSTEIN, Richard S, PhD - Professor, Nutritional Sciences. Affiliated with METC since 1996. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant, Cellular and Genetic Toxicology. Iron. Regulation of iron metabolism. Molecular regulation of the synthesis of iron transport and storage proteins.
ELFARRA, Adnan A, PhD - Professor of Toxicology, Department of Comparative Biosciences, Division of Pharmaceutical Sciences, School of Pharmacy. Affiliated with METC since 1987. TRAINER and PI on Pre- and Post Doctoral Training Grant. Deputy PI and TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Cellular and Molecular Basis for Toxicity and Target Organ Selectivity. Cellular and Genetic Toxicology. Toxicant and carcinogen metabolism. Mechanisms of toxicity and target organ selectivity. DNA and hemoglobin modifications. Toxicity of the industrial chemicals trichloroethylene, tetrachloroethylene, 1,3-butadiene, and related compounds. Advisor to METC Graduate Students and Trainees: Roy Irving (current), Rachel Novick (current), Joe Dever (2008), Christopher Sprague (2004), Sjofn Gunnarsdottir (2002), Sharon Ripp (1998), Rebecca Selzer (1997), Jane Sharer (1993), Peter Sausen (1992), In Young Hwang (1992), Renee Krause (1992)
ENGELMAN, Corinne D., PhD - Assistant Professor, Population Health Sciences. Affiliated with METC in April 2009.
FABRY, Zsuzsanna, PhD - Department of Pathology and Laboratory Medicine, Affiliated with METC from 2006 to present. Immunopathology, Neuroimmunology, Multiple Sclerosis. Advisor to METC Graduate Students: Delinda Johnson (current)
GOULD, Michael N, PhD - Professor, Oncology. Affiliated with METC since 1979. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Molecular Biology of Breast Cancer. Identification of genes that prevent breast cancer. Signaling pathway differences between H-Ras and K-Ras oncogenes and role in organ-specific carcinogenesis. Molecular basis of selective cell death and proliferation inhibition through study of effects of monoterpene drugs and other potential chemoprotective agents. Breast cancer risk assessment by surrogate biomarkers. Advisor to METC Graduate Students: Tai Yu-Tzu (1996), Sandra Eldridge (1988), Jennifer Ariazi (2003) Mentor to METC Post-Doc: Michele Cotroneo (2004), Lauri Shepel (1991-1992), Lisa Seidman (1985-1986)
GRIEP, Anne E, PhD - Professor, Anatomy. Affiliated with METC since 1998. Vertebrate Eye Development. Cell Cycle and Adhesion. Environmental and toxicant damage on function of ocular tissues. Molecular and genetic regulation of cell proliferation, differentiation and apoptosis in the vertebrate eye.
HANDELSMAN, Jo, PhD - Professor, Plant Pathology. Affilaited with METC since 2004. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. Antibiotic Resistance Genes. Structure and function of microbial communities. Impact of antibiotics on distribution of antibiotic resistance genes in soil.
HEIDEMAN, Warren, PhD - Professor, Pharmaceutical Sciences. Affiliated with METC since 1997. TRAINER on the METC TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. Trainer on NIEHS Short-Term Research Training for Minority Students Grant. Cellular and Genetic Toxicology. Developmental toxicology of TCDD in zebrafish. Regulation of yeast cell cycle by signal transduction pathways. Advisor to METC Graduate Students and Trainees: Vatsal Mehta (2009), Dagmara Antkiewicz (2007), Bing Liu (1996)
HICKEY, William J, PhD - Professor, Soil Science. Affiliated with METC since 1990. Associate Director of METC graduate program. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Bioavailability of Agents in Remediation. Bacterial metabolism of xenobiotics. Bioremediation of contaminated soil and groundwater. Use of nucleic acid probes to study microbial populations in soil and groundwater. Advisor to METC Graduate Students: Ameesha Shetty (current), Emily Burton (Masters 2004), Alice Yuroff (2002), Michele Zwolinski (2001), Scott Arnold (1995)
HUTTENLOCHER, Anna, MD - Professor, Pediatrics and Medicine. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. Current projects in the laboratory employ many different techniques including (1) cell culture, (2) time lapse videomicroscopy and other assays of cell migration both in cultured cells and within living organisms (3) ectopic expression of genes carrying site-directed mutations, (4) fluorescence microscopy (use of GFP-fusion proteins) and (5) gene discovery by expression cloning and retroviral knock out techniques. Mentor to METC Post-Doc: >Peter Cavnar (current)
JARRARD, David F, MD, PhD - Professor, Surgery, Urology. Affiliated with METC since 1997. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Prostate Cancer. Oxidative Stress. Insulin-Like Growth Factor II. DNA methylation in cancer development Molecular genetics of prostate cancer. Advisor to METC Graduate Students: Josh Desotelle (current), J. Lea Roberts (MS 2007)
JEFCOATE, Colin R, PhD - Professor, Molecular and Cellular Pharmacology. Affiliated with METC since xxxx. TRAINER on METC NIEHS Pre- and Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Roles of cytochrome P4501B1 and Ah Receptor in fat pad development, bone marrow toxicity and carcinogenesis in susceptible mouse strains (intestines, prostate, and mammary gland). Effects of polycyclic aromatic hydrocarbons and PCBs in these processes Molecular mechanism of cholesterol conversion to steroid hormones. Effects of obesity and steroid synthesis and carcinogenesis. Advisor to METC Graduate Students: Melissa Cimafranca (2006), Noe Galvan (2004), Paul Hanlon (2003), David Alexander (1999), Leo Ganem (1999), Paul Brake (1997), Michael Dibartolomeis Jr (1984). Mentor to METC Post-Docs: Sakina Eltom (1996), Shelley Larsen-Su (1999), Craig Marcus (1983-1984), Maro Christou (1984 & 1986)
JEFFRIES, Thomas W, PhD - Professor, Bacteriology. Affiliated with METC since 2003. Xylose. Yeasts. Metabolic Engineering. Alternative and Renewable Fuels. Microbial physiology and metabolic regulation as they apply to the use of lignocellulosic materials. Interdisciplinary research involving screening, scale-up, microbial biochemistry, and molecular genetics. Fermentation of xylose by yeasts. Use of xylanases, cellulases and ligninases in pulp and paper processing. Advisor to METC Graduate Students: JuYun Bae (2008)
JOHNSON, Eric A, PhD - Professor, Bacteriology. Affiliated with METC since 1999. Natural Toxins. Botulinum Neurotoxin. Clostridum Botulinum. Foodborne Pathogens. Genetics and biochemistry of botulinum toxin, the isolation and characterization of antimicrobial compounds from natural sources, and the biosynthesis of carotenoid pigments in yeasts found in unusual ecological niches. Advisor to METC Graduate Students: Joanna Bultman (current), Sherly Bellevue (MS-2007)
JOHNSON, Jeffrey A, PhD - Professor, Pharmaceutical Sciences. Affiliated with METC since 1999. (METC Alumni 1992) TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Alzheimer's. Amyotrophic Lateral Sclerosis. Huntington's. Parkinson's. Autoimmune Disease. Molecular mechanism of tert-butylhydroquinone (tBHQ) activation of Antioxidant Response Element-driven genes in neuroblastoma cells, primary neuronal and glial cultures, and in vivo. How ARE-driven genes block cell death. Effect of overexpression of amyloid precursor protein on the ARE and antioxidant genes in neurons and glia. Advisor to METC Graduate Students: Marcus Calkins (2008), Jong-Min Lee (2003). Mentor to METC Post-Docs: Neal Burton (current), Jon Kern (2004), Julie Kern (2004)
KAMP, Timothy J., PhD - Professor, Medicine - Affiliated with METC in April 2009.
KANAREK, Marty S., PhD, M.P.H. - Professor, Population Health Sciences. Affiliated with METC since 1979. Environmental Epidemiology and Health. Mercury. Lead. PCBs. Environmental epidemiology. Cancer epidemiology. Environmental health. Air and water pollution. Mentor to METC Post-Doc: Gherry Harding (1981)
KARASOV, William H, PhD - Professor, Forest & Wildlife Ecology. Affiliated with METC since 1986. Ecotoxicology. Wildlife. Amphibians. Bioavailability. Absorption. Plant Toxins. Physiological and ecological effects on wildlife of naturally occurring toxicants in their food and of environmental toxicants. Mechanisms of intestinal absorption and effects of toxicants on absorptive processes. Advisor to METC Graduate Students: Jeff Lorch (current), John Allran (MS 1999) Mentor to METC Post-Docs: Walter Jakubas (1989)
KASPAR, Charles W, PhD - Professor, Bacteriology. Affiliated with METC since 1999. Acidophiles; microbial ecology; host–pathogen interactions. Research focus is on the isolation and characterization of acidophilic archaea, bacteria, and fungi. One area of emphasis is identifying and defining the function of proteins that protect or repair biomolecules, i.e. DNA. Studies with enterohemorrhagic E. coli O157:H7 are aimed at defining population dynamics and evolutionary processes affecting frequency and distribution. A variety of molecular and physiological approaches are used in these studies.
KEELY, Patricia, PhD - Associate Professor, Pharmacology. Affiliated with METC since 2007. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. Cancer Biology, Cell Structure, Extracellular matrices, Cell Migration and Cell Communication. Appropriate cellular interactions with the extracellular matrix (ECM) help to establish normal cellular architecture and differentiation. During oncogenic transformation, these normal interactions with the ECM are profoundly altered, resulting in cells that lose their polarization and differentiation, lose anchorage dependent growth control, and acquire a migratory, invasive phenotype. Also interest in understanding, at a molecular level, how cellular interactions with the ECM determine differentiation and epithelial polarization, and how these interactions are altered during carcinogenesis to result in invasive, metastatic carcinoma. Mentor to METC Post-Doc: Suzanne Ponik (2008-09)
KELLER, Nancy P, PhD - Professor, Medical, Microbiology, and Food Microbiology & Toxicology, Microbiology, and College of Agriculture and Life Sciences, Plant Pathology. Affiliated with METC since 2002. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Host-Fungal Interactions. Invasive aspergillosis in immunocompromised patients; molecular genetics of mycotoxin biosynthesis; fungal development; host-fungal interactions leading to toxin production and sporulation. Mentor to METC Post-Docs: Graeme Garvey (current), Marion Brodhagen (2006)
KLEIN, Bruce S., MD - Professor, Pediatrics, Internal Medicine and Medical Microbiology and Immunology. Affiliated with METC in 2008. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. Molecular medical mycology - cellular and molecular basis of immunity to medical fungi; genetics of virulence; molecular mechanisms of pathogenesis. Advisor to METC Trainee: Rene Roy (current)
KREEGER, Pamela, PhD - Assistant Professor, Biomedical Engineering. Affiliated with METC in April 2009.
LAN, Que, PhD - Associate Professor, Department of Entomology Affiliated with METC in April 2009.
LEE, Youngsook, PhD - Associate Professor, Anatomy. Affiliated with METC since 2001. Cardiac Development. Molecular pathways controlling cardiovascular development and maintenance of normal cardiac phenotype; transcription factors and signal transduction; isolation and characterization of stem cell-derived cardiomyocytes. Advisor to METC Graduate Student: Matt Brody (current)
LI, Lingjun, PhD - Associate Professor, Pharmaceutical Sciences. Affiliated with METC in April 2009.
LINDROTH, Richard L, PhD - Professor, Entomology. Affiliated with METC since 1988. Ecology. Global Environmental Change. Plants. Natural Products. Ecotoxicology. Physiological and biochemical mechanisms underlying ecological interactions between plants and herbivores. Natural products toxicology. Advisor to METC Graduate Students: Jocelyn Hemming (1998), Rob Thiboldeaux (1996), Cynthia Thompson (1996)
LONG, Sharon C, PhD - Associate Professor, Soil Science. Affiliated with METC since 2007. Applied Environmental Microbiology
MUKHTAR, Hasan, PhD - Helfaer Professor of Cancer Research, Dermatology Affiliated with METC since 2006. TRAINER on the METC NIEHS Pre-Post Doctoral Training Grant. Apoptosis, Chemical Carcinogenesis, Chemoprevention, Cytochrome P450, Metabolic Basis of Toxicity, Photocarcinogenesis, Tumor Promotion/Prevention. Advisor to METC Graduate Students: Deeba Syed (current), Rohinton Tarapore (current)
NIETO, F. Javier, MD, PhD, MPH - Helfaer Professor of Public Health; Department of Population Health Sciences. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. Impact of environment on cardiovascular disease. Epidemiology, markers of subclinical atherosclerosis, emerging risk factors for cardiovascular disease (homocysteine, inflammation markers, chronic infections), health consequences of sleep disorders and psychosocial stress. Also interested in methodological issues in epidemiology and in the teaching of epidemiologic methods.
NTAMBI, James M, PhD - Professor, Biochemistry. Affiliated with METC since 1996. Gene Regulation. Fat Cell Differentiation. Fat cell differentiation and dietary and hormonal regulation of gene expression.
OBERLEY, Terry D, PhD - Professor, Pathology and Laboratory Medicine. Affiliated with METC since 1985. Oxidation. Cancer. Cell Cycle. Redox. Advanced Microscopy. Cellular and Genetic Toxicology. Role of reactive oxygen metabolism in cell division and carcinogenesis. Advisor to METC Graduate Students: Weihua Shan (current), Aekyong Kim (2004), Yafan Li (2005)
PARIZA, Michael W, PhD - Professor, Food Microbiology and Toxicology. Affiliated with METC since 1977. Cancer and Diet. Conjugated Linoleic Acid. Chemical carcinogenesis. Nutrition and cancer. Advisor to METC Graduate Students: Nancy Erdman (MS 1983), Debra Gayda (1982), Xiaofnag Xu (2002). Mentor to METC Post-Docs: Nina Mattarella (1981-1983), John Sword (1988-1990)
PEDERSEN, Joel A, PhD - Associate Professor, Soil Science. Affiliated with METC since 2001. TRAINER on METC NIEHS Pre- and Post Doctoral Training Grant. Fate, transport and bioavailability of organic toxicants and engineered nanoparticles in terrestrial and aquatic environments. Environmental transmission of prion diseases. Advisor to METC Graduate Students: Clarissa Booth (current), Kartik Kumar (current), Paige Wiecinski (current), Sarah Yang (current), (Kennedy) Ned Rubert (2008), Heidi Bialk (2006), and Kristin Phillips (MS-2005)
PETERSON, Richard E, PhD - Professor, Pharmaceutical Sciences. Affiliated with METC since 1977. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. AhR Signaling. Reproductive and Developmental Toxicology. Mouse and zebrafish, Dioxin (TCDD), Prostate Growth, Development and Cancer, Heart Development, Nanotoxicology. Advisor to METC Graduate Students: Sarah Allgeier (2007), Emmie Dengler (MS 2007), Sara Carney (2005), Amy Prasch (2004), Eric Andreasen (2001), Christian Abnet (1998), Michael Hornung (1998), James Kleeman (1998), Beth Roman (1997), Erick Zabel (1995), Jack VandenHeuvel (1991), and Mark Seefeld (1982). Mentor to METC Post-Docs: Wayne Fritz (2003), Carl Potter (1982-1983), Mary Vomachka (1984-1985), Shahanara Saroya (1991-1992), Robert Tanguay (1996-1997), Tisha King Heiden (2006-2008), Susan Bello (2000-2001), Tracie Baker (current)
PORTER, Warren P, PhD - Professor, Zoology. Affiliated with METC since 1987. Effect of Multiple Stresses. Ecotoxicology. Multiple low level stresses such as from climate, toxicants, disease, or nutrition, affecting immune, endocrine, neurological systems, growth, reproduction and development potential, population dynamics and community structure. Advisor to METC Graduate Students: Javier Velasco (present), Mark Jankowski (2007), Cynthia Boyd (MS 1988),
PROLLA, Tomas A, PhD - Professor, Genetics. Affiliated with METC since 1997. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. DNA Repair. Cancer. Aging. Generation of animal models of human cancer syndromes using gene targeting in the mouse. Role of DNA repair in spontaneous and induced mutagenesis. Signal transduction pathways involved in DNA repair. Advisor to METC Graduate Students: Cheol-Koo Lee (2002)
REED, Jess D, PhD - Professor, Animal Sciences. Affiliated with METC since 1992. Toxicant Behavior and Remediation. Toxicology and effects of phytochemicals in foods and feeds on human and animal health and nutrition.
SANDGREN, Eric P, VMD, PhD - Associate Professor, Pathobiological Sciences. Affiliated with METC since 1995. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Genetic and Extracellular Regulation of Tissue Growth. Molecular mechanisms of carcinogenesis; transgenic mouse models of cancer genetics. Studies of xenogeneic transplantation and human hepatocyte biology in rodents. Advisor to METC Graduate Students: Patricia Boley (current), Ly Pham (current), Teresa Weglarz (2000). Mentor to METC Post-Docs: Teresa Rose-Hellekant (1997-1998)
SCHULER, Linda A, VMD, PhD - Professor, Comparative Biosciences. Affiliated with METC since 1997. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Hormonal Effects in Breast Cancer and Human Development. Prolactin and related hormones' receptors, signaling and processing; cell specific actions on maternal and fetal tissues, and role in mammary cancer. Advisor to METC Graduate Students: Jennifer Gutzman (2004).
SETALURI, Vijay, PhD - Associate Professor, Dermatology. Affiliated with METC since 2006. Biology of melanocytes and melanoma.
SHEIBANI, Nader, PhD - Associate Professor, Ophthalmology & Visual Science. Affiliated with METC since 2001. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant and Short-Term Research Minority Training Grant. Vascular Biology. Regulation of angiogenesis, cellular adhesive mechanisms, focal adhesion and integrin signal transduction, pathological neovascularization and eye diseases. Advisor to METC Graduate Student: Tammy Elmergreen (current), Yun Zhao (current)
SMITH, Susan M, PhD - Professor, Nutritional Science. Affiliated with METC since 1996. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Human Development and Risk. Risk and mechanism underlying trichloroethylene-induced cardiac defects. Fetal Alcohol Syndrome. Retinoids. Trichloroethylene. Molecular mechanism underlying alcohol-related birth defects (ethanol-dependent signal transduction and Ca2+ transients in triggering neuronal apoptosis). Retinoid action in fetus and adult, with emphasis on vitamin A status and heart function. Advisor to METC Graduate Students: Echoleah Rufer (current), Fernandez Cavieres (2001), Katherine Kragtorp (2003), Evan Thackaberry (2002),
SONZOGNI, William C, PhD - Professor, Environmental Health. Affiliated with METC since 1986. Environmental Chemistry. Aquatic Chemistry. Environmental Contaminants. Water Chemistry, Civil and Environmental Engineering. Interdisciplinary environmental problems, with special emphasis on the North American Great Lakes: applied aquatic chemistry, quantification of pollutant loads, short-term assays of acute and chronic toxicity, toxic algae and the human and environmental risks of toxic contaminants.
SPIEGELMAN, Vladimir S, MD, PhD - Associate Professor, Dermatology. Affiliated with METC since 2005. Cancer. Ubiquitin Ligases. Signal Transduction. Regulation of expression and function of beta-TrCP ubiquitin ligases, their role in signal transduction, embryogenesis, and in tumor development, with major emphasis on skin, breast, and prostate carcinogenesis.
SUSSMAN, Michael R, PhD - Professor, Biochemistry. Affiliated with METC since 1996. Cellular and Genetic Toxicology. Molecular basis of signal transduction and solute transport at the plasma membrane of Arabidopsis thaliana, a model higher plant. Isolation of 'knockout' plants for testing the in situ function of cloned genes. Advisor to METC Graduate Students: Roland Green (1999)
TIBBETTS, Randal S, PhD - Associate Professor, Pharmacology - TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. Attempting to understand how mammalian cells respond to genetic damage, with emphasis on the ATM/ATR family of tumor suppressor genes. Also is also exploring the process of neurodegeneration in ataxia-telangiectasia (A-T), an inherited genetic disease that results from mutations in ATM. By identifying defective pathways in A-T, it is hoped that more can be learned about other neurodegenerative conditions such as Parkinson's disease and Alzheimer's, which may share common roots with A-T. Advisor to METC Graduate Student: John Hutchinson (current)
TREPANIER, Lauren A, DVM, PhD - Professor, Medical Sciences. Affiliated with METC since 1997. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Drug Hypersensitivity. HIV. Drug Detoxification. Cytochrome b5 Reductase. Genetic and biochemical variability in drug metabolism and its relationship to adverse drug reactions and drug toxicity. Arylamines, nitroso compound and hydroxylamines. Sulfonamide drug hypersensitivity in AIDS patients. Therapeutic drug monitoring for veterinary patients. Advisor to METC Graduate Students: Keelia Rhodes (current), Joe Kurian (2006)
VERMA, Ajit K, PhD - Professor, Human Oncology. Affiliated with METC since 1985. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. Research goals: Defining mechanisms of skin and prostate cancer using transgenic and gene knock-out models. Protein kinase C signaling in cancer induction. Caner chemoprevention. Advisor to METC Graduate Students: Jordan Sand (current)
VEZINA, Chad M. - Assistant Professor, Animal Health & Biomedical Sciences. Affiliated with METC July 2009.
WATTERS, Jyoti, PhD - Associate Professor, Comparative Biosciences. Affiliated with METC since 2006. Understanding the molecular signal transduction pathways in microglia in response to estrogens and extracellular adenine nucleotides that modulate their production of neurotoxic inflammatory mediators.
WILDING, George, PhD - Professor, Comprehensive Cancer Center. Prostate Cancer. Affiliated with METC since1989. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Prostate carcinogenesis; steroid and growth factor mediated growth control mechanisms; mechanisms of action of cytotoxic agents; drug resistance (chemotherapy agents). Advisor to METC Graduate Students: Elyse Lee (2005), Maureen Ripple (1996)
WONG, Amy C, PhD - Professor, Bacteriology. Affiliated with METC since 1999. Biofilm formation and control. Enterotoxins of Bacillus cereus and Staphylococcus aureus.
XING, Yongna, PhD - Assistant Professor, Oncology Affiliated with METC since 2008. Cell signaling. Cell metabolism. Genome integrity. Cellular and Genetic Toxicology Cancer. Protein x-ray crystallography. Proteomics. Biochemistry
XU, Wei, PhD - Assistant Professor, Oncology Affiliated with METC since 2008. TRAINER on the METC NIEHS Pre-Post Doctoral Training Grant. Breast cancer prevention and treatment using environmental and nutritional estrogenic compounds. Developed assays for identification of novel natural estrogenic ligands. Molecular mechanism of transcription activation of ERa and ERb by environmental estrogenic ligands. Epigenetic changes in breast cancer and biomarker discovery for breast cancer diagnosis and prognosis. Advisor to METC Graduate Student: Erin Shanle (current)
YU, Jaehyuk, PhD - Associate Professor, Bacteriology. Affiliated with METC since 2001. Fungi. Toxins. Development. Signal Transduction. RGS Protein. Gene Regulation. Molecular genetics of filamentous fungi. Signaling mechanisms controlling fungal growth, development and mycotoxin production, genetics and biochemistry of mycotoxin (aflatoxin, trichothecenes, fumonisin) biosynthesis. Signal transduction mechanisms coordinated by Heterotrimeric G-proteins and Regulator of G-protein signaling (RGS) proteins. Advisor to METC Graduate Students: HeeSoo Park (current), Na Gao, (MS-2008), Yajun Guan, (MS 2003)
ZHANG, Jing, PhD - Assistant Professor, Oncology. - Affiliated with METC April 2009.
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