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Blanke, Kristina
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Boley, Patricia
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Booth, Clarissa
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Brody, Matthew
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Irving, Amy
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Irving, Roy
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Johnson, Brian
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Johnson, Delinda
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Johnson, Shaina
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Jung-Hynes, Brittney
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Kumar, Kartik
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Lee, Sung-Kyoung
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Mehta, Vatsal
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Sand, Jordan
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Schmit, Travis
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Shan, Weihua
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Tarapore, Rohinton
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Yang, Sarah
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Yu, Min
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Zhao, Yun
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Calkins, Marcus
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Jung-Hynes, Brittney
 Brittney Jung-Hynes - Email
PhD Candidate - Started 2005
Native of Randolph, WI
Lab of Nihal Ahmad, PhD
Undergraduate Work
University of Wisconsin-Madison (2001-Present)
Bachelor of Science, Pharmacology & Toxicology (2005)
Memberships
Associate Member of American Association for Cancer Research
Associate Member of American Society for Photobiology
Interests/Hobbies
Softball, Volleyball, Tennis and Scrapbooking
Current Funding
National Institute of Environmental Health Sciences
T32 ES 007015 (May 1, 2007 to present)
Molecular and Environmental Toxicology Pre-& Postdoctoral
Research as of October 2008
Prostate cancer (PCa) is a major age-related malignancy and according to estimates from the American Cancer Society, a man's chance of developing this cancer significantly increases with increasing age. There appears to be a link between aging and PCa, therefore, it will be interesting to identify the causal connection between mechanisms of aging and prostate cancer. Sirt1 is a nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase, which belongs to the Silent information regulator 2 (Sir2) family of sirtuin class III histone deacetylases (HDACs). Sir2, yeast homologue of Sirt1, is involved in a number of cellular processes. Recent studies demonstrated that Sirt1 plays an important role in the regulation of cell fate and promotes cell survival by modulating apoptosis and/or cellular senescence, the two important tumor suppressor mechanisms which have evolved in organisms. An increasing number of critical proteins have been identified as substrates of Sirt1, including p53 and Forkhead-box Class O (FoxO) transcription factors. I have recently found that Sirt1 is overexpressed in human PCa cells compared to normal prostate epithelial cells at a variety of levels. Sirt1 was also found to be overexpressed in human PCa tissues compared to normal prostate tissues. Further, my data collected thus far has shown that Sirt1 inhibition by nicotinamide as well as shRNA-mediated RNA interference causes an inhibition in growth of human PCa cells. Based on these novel observations and available literature, I propose to test the hypothesis that Sirt1 plays a critical role in the etiology and development of prostate cancer. Thus, my working hypothesis that will be tested is that inhibition of Sirt1 will result in cell cycle arrest, apoptosis or senescence of human prostate cancer cells via binding to and/or inhibiting deacetylation of p53 and/or FoxO transcription factors - directly or indirectly via deacetylation of p300 and CREB-binding protein (CBP).
Publications
Jung-Hynes B, Ahmad N. Role of p53 in the anti-proliferative effects of Sirt1 inhibition in prostate cancer cells. Cell Cycle. 2009 May 13;8(10)
Jung-Hynes B, Nihal M, Zhong W, Ahmad N. Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition?. J Biol Chem. 2009 Feb 6;284(6):3823-32
Jung, B., and Ahmad, N. (2006) Melatonin in Cancer Management: Progress and Promise. Cancer Research 66:(20), 9789-9793
Posters
A targeted knockdown of sirtuin histone deacetylase Sirt1 imparts significant growth inhibitory effects in human prostate cancer cells. (Poster presented at 2008 AACR meeting in San Diego)
Involvement of Sirt1 in Ultraviolet radiation mediated damages and transformation of skin keratinocytes. (Poster presented at 2008 AACR meeting in San Diego)
Differential anti-proliferative effects of melatonin in prostate cancer cells versus normal prostate cells: Involvement of senescence and cell cycle as dual modes of action - Brittney Jung1,2 and Nihal Ahmad1,2
1Department of Dermatology, University of Wisconsin, Madison, WI.
2Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, WI.
(Poster presented at 2007 AACR meeting in Los Angeles by Brittney Jung)
SIRT proteins as novel targets for the management of prostate cancer.
Brittney Jung1,2, Weixiong Zhong3, Nihal Ahmad1,2
1Department of Dermatology, University of Wisconsin, Madison, WI.
2Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, WI.
3Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI.
(Poster presented at 2007 AACR meeting in Los Angeles by Brittney Jung)
Travis Schmit
Nihal Ahmad, PhD
Brittney Jung
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