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- Current Students
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Blanke, Kristina
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Boley, Patricia
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Bolterstein, Elyse
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Booth, Clarissa
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Brody, Matthew
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Bultman, JoAnna
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Burns, Felipe
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Desotelle, Josh
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Ding, Lina
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Elmergreen, Tammy
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Hutchinson, John
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Irving, Amy
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Irving, Roy
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Johnson, Brian
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Johnson, Delinda
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Johnson, Shaina
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Jung-Hynes, Brittney
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Kumar, Kartik
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Lee, Sung-Kyoung
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Lorch, Jeff
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Mehta, Vatsal
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Novick, Rachel
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Park, Heesoo
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Pham, Ly
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Poenitzsch, Ashley
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Rhoads, Keelia
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Rufer, Echoleah
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Sand, Jordan
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Schmit, Travis
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Shan, Weihua
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Shanle, Erin
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Shetty, Ameesha
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Syed, Deeba
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Tarapore, Rohinton
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Velasco, Javier
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Wiecinski, Paige
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Wong, Letitia
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Yang, Sarah
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Yu, Min
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Zhao, Yun
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Calkins, Marcus
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Rhoads, Keelia
 Keelia Rhoads - Email
PhD Candidate - Started 2005
Native of Carlinville, IL
Lauren A. Trepanier, PhD.
Undergraduate Work
Illinois Wesleyan University
Bachelor of Science, Biology (2005)
Funding
National Research Service Award Predoctoral Traineeship (NIEHS Training Grant T32, beginning 10/2006)
Interests/Hobbies
volleyball, softball, running, singing, reading.
Research as of September 2007
Carcinogens such as 4-aminobiphenyl (ABP), found in tobacco smoke, and 2-amino-1-methyl-6-phenylimidazo [4,5-b]-pyridine (PhIP), found in grilled meats, can form adducts that initiate cancer. While these adducts have been identified in normal breast and breast cancer tissue as well as the milk of nursing mothers, there still is no consensus on the role that smoking or eating grilled meats may play in the formation of breast cancer. Inconsistent findings could be due to the inability to adequately control for individual differences in the enzymes that metabolize arylamine carcinogens.
Before adduct formation, arylamine carcinogens must be activated to produce hydroxyl amine metabolites, but we have shown that these reactive metabolites can be detoxified by a microsomal reduction pathway containing NADH cytochrome b5 reductase (b5R) and cytochrome b5 (cyt b5). It has been demonstrated that both of these enzymes are present in human breast tissue. The goal of my research is to determine whether the model carcinogen N-OH-ABP is detoxified in breast tissue by cyt b5 and b5R. I also want to determine if differences in DNA adduct formation can be attributed to differential expression or activity of these two enzymes in breast tissue. I also will determine if genetic variability in cyt b5 or b5R affects the susceptibility of acquiring breast cancer in women who are exposed to environmental arylamine carcinogens. It is our hope that these results will provide some explanations for the mixed findings of risk of breast cancer among various epidemiologic studies.
 Posters
Weir, M.E., Rhoads K.M., Fei H., and Borst D.W. Nutritional effects on vitellogenesis in the lubber grasshopper. Society for Integrative and Comparative Biology Annual Meeting. New Orleans, LA, Jan 2004.
Lauren Trepanier, PhD
Keelia Rhoads
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