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Blanke, Kristina
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Boley, Patricia
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Bolterstein, Elyse
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Booth, Clarissa
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Brody, Matthew
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Bultman, JoAnna
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Burns, Felipe
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Desotelle, Josh
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Ding, Lina
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Elmergreen, Tammy
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Hutchinson, John
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Irving, Amy
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Irving, Roy
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Johnson, Brian
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Johnson, Delinda
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Johnson, Shaina
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Jung-Hynes, Brittney
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Kumar, Kartik
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Lee, Sung-Kyoung
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Lorch, Jeff
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Mehta, Vatsal
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Novick, Rachel
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Park, Heesoo
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Pham, Ly
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Poenitzsch, Ashley
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Rhoads, Keelia
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Rufer, Echoleah
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Sand, Jordan
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Schmit, Travis
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Shan, Weihua
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Shanle, Erin
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Shetty, Ameesha
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Syed, Deeba
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Tarapore, Rohinton
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Velasco, Javier
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Wiecinski, Paige
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Wong, Letitia
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Yang, Sarah
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Yu, Min
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Zhao, Yun
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Calkins, Marcus
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Tarapore, Rohinton
 Rohinton Tarapore - Email
PhD Candidate - Started 2005
Hails from Bombay, India
Lab of Hasan Mukhtar, PhD
Undergraduate and Graduate Work
Wayne State University, MI (2002-2004)
Masters of Science (Biological) (2004)
University of Mumbai, India (1998-2000)
Masters of Science-Zoology specializing in Physiology (2000)
St. Xavier's College, Mumbai, India (1995-1998)
Bachelors of Science, Zoology & Biochemistry (1998)
Memberships
Smithsonian Society
National Geographic Society
University of Wisconsin - Stem Cell & Regenerative Medicine Center (UW-SCMRC)
Interests/Hobbies
Discussing science, traveling, experiencing the outdoors, biking, whitewater rafting
Research as of Spring 2008
In the absence of Wnt, beta-catenin is recruited into a destruction complex leading to its ubiquitination and degradation by the proteosomes. The on-state of Wnt signaling results in post-translational stability by degradation of this complex. Accumulation of beta-catenin in the nucleus activates transcription of beta-catenin/TCF target genes. Our lab recently found a target gene for beta-catenin namely CRD-BP. This CRD-BP binds and stabilizes mRNA of several genes (including c-myc and b-TrCP). Studies have shown that a third of the melanomas have upregulated Wnt expression and NF-kB is activated in most epithelial tumors. My immediate aim is to assess the role of CRD-BP in melanoma development. To this end, I am planning to analyze the expression of CRD-BP in primary tumorigenic properties of melanoma cell lines.
My research also includes the study of a chemopreventive agent Lupeol and its effect on melanomas. We plan to expose various melanoma cell lines to this agent and study the expression of CRD-BP and various other proteins.
Publications- Saleem M, Murtaza I, Tarapore RS, Suh Y, Adhami VM, Johnson JJ, Siddiqui IA, Khan N, Asim M, Hafeez BB, Shekhani MT, Li B, Mukhtar H. Lupeol inhibits proliferation of human prostate cancer cells by targeting beta-catenin signaling. Carcinogenesis. 2009 May;30(5):808-17.
- Elcheva I, Tarapore RS, Bhatia N, Spiegelman VS. Overexpression of mRNA-binding protein CRD-BP in malignant melanomas. Oncogene. 2008 Aug 28;27(37):5069-74.
- Sonde V, D'souza A, Tarapore R, Pereira L, Khare MP, Sinkar P, Krishnan S, and Rao CV - Simultaneous administration of diethylphthalate and ethyl alcohol and its toxicity in male Sprague-Dawley rats. Toxicology. 2000 May 19;147(1):23-31
Posters
Overexpression of mRNA binding protein CRD-BP in malignant melanomas - R. Tarapore, I. Elcheva, N. Bhatia and V. Spiegelman. University of Wisconsin Comprehensive Cancer Center (UWCCC) research retreat (February 2008).
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