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- Current Students
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Student Resources
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Student Publications
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Blanke, Kristina
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Boley, Patricia
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Bolterstein, Elyse
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Booth, Clarissa
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Brody, Matthew
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Bultman, JoAnna
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Burns, Felipe
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Desotelle, Josh
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Ding, Lina
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Elmergreen, Tammy
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Hutchinson, John
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Irving, Amy
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Irving, Roy
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Johnson, Brian
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Johnson, Delinda
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Johnson, Shaina
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Jung-Hynes, Brittney
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Kumar, Kartik
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Lee, Sung-Kyoung
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Lorch, Jeff
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Mehta, Vatsal
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Novick, Rachel
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Park, Heesoo
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Pham, Ly
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Poenitzsch, Ashley
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Rhoads, Keelia
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Rufer, Echoleah
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Sand, Jordan
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Schmit, Travis
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Shan, Weihua
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Shanle, Erin
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Shetty, Ameesha
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Syed, Deeba
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Tarapore, Rohinton
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Velasco, Javier
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Wiecinski, Paige
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Wong, Letitia
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Yang, Sarah
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Yu, Min
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Zhao, Yun
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Calkins, Marcus
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Irving, Roy
 Roy Irving - Email
PhD Candidate - Started 2007
Rockville, Maryland
Lab of Adnan Elfarra, PhD
Undergraduate Work
Georgetown University - Washington DC (2001-2005)
Bachelors of Science - Biochemistry (2005)
Research as of Fall 2008
Exposure to halogenated hydrocarbons, a family of chemicals used in industrial and agricultural applications, has been linked to many deleterious effects including carcinogenesis, mutagenicity, and nephrotoxicity. Bioactivation by the endogenous cellular machinery is often a major contributor to the overall toxicity of the compound. One prominent mechanism of bioactivation is the formation of reactive electrophilic metabolites, which can form covalent adducts with cellular macromolecules, resulting in alteration of the cellular function of the targeted protein, lipid, or nucleic acid. My research will focus on covalent modification and protein crosslinking by metabolites of halogenated hydrocarbons and the connection between this pathway and nephrotoxicity. One aspect of my project will be to determine the mechanistic steps that contribute to the biological effects that manifest with exposure. In addition, part of my research project will involve the identification of biomarkers of exposure. Development of biomarkers can greatly increase the efficiency and accuracy of determining the extent of population exposure and as a result can have great benefits to public health.
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